? What is Hyperthermia?A
Hyperthermia is a type of cancer treatment in which tumors are exposed to elevated body temperatures, between 104˚ and 113°F. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. Higher temperatures selectively damage cells that are hypoxic and have low pH, a condition of tumor cells and not a condition of normal cells. Hyperthermia has been shown to inhibit cellular repair mechanisms, induce heat-shock proteins, denature proteins, induce apoptosis, and inhibit angiogenesis.
- Tumour hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues.
- Heat shock proteins are a family of proteins that are produced by cells in response to exposure to stressful conditions.
- Apoptosis is the process of programmed cell death (PCD) Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.
? What is Superficial Hyperthermia?ASuperficial hyperthermia approaches are used to treat tumors that are in or just below the skin. External applicators are positioned around or near the appropriate region, and energy is focused on the tumor to raise its temperature.
The BSD-500 is used shown excellent results in clinical studies on recurrent and progressive Melanoma,Squamous or basal-cell carcinoma, Sarcoma and Adenocarcinoma.
? What is Deep Regional Hyperthermia?AThe BSD-2000 provides deep regional therapeutic hyperthermia to solid tumors by applying radiofrequency (RF) energy at the frequency range of 75 to 120 MHz. The BSD-2000 delivers energy to a patient using a power source and an array of multiple antennae that surround the patient’s body. The system provides an optimized heating zone targeted to the tumor region by utilizing the adjustment of frequency, phase, and amplitude from multiple power sources. The energy can be focused electronically to the tumor region, thus providing dynamic control of the heating delivered to the tumor region.
? How does Hyperthermia work with Radiation Therapy?AHyperthermia increases the effectiveness of radiation therapy due to the independent cytotoxic effects of hyperthermia combined with its radiosensitizing effects. Hyperthermia increases blood flow, resulting in improved tissue oxygenation and thus increased radiosensitivity. Hyperthermia also interferes with cellular repair of the DNA damage caused by radiation. Hyperthermia damages cells that are hypoxic, have a low pH, and are in the S-phase of division, which are all conditions that make cells resistant to radiation therapy. The addition of hyperthermia does not usually increase toxicity of radiation therapy.
? How does Hyperthermia work with Chemotherapy?AHyperthermia used in combination with chemotherapy increases the drug concentration in the tumor region duet to increased blood flow, thus raising the effectiveness of cytostatic drugs. In addition hyperthermia has been proven to enhance drug toxicity in cells resistant to many drugs.